2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00010
    Dazopride 70181-03-2 98%
    Dazopride is an antiemetic agent.
    Dazopride
  • HY-U00012
    Glyhexamide 451-71-8 98%
    Glyhexamide is an effective hypoglycemic agent in adult diabetics.
    Glyhexamide
  • HY-U00014
    AVE-8134 304025-09-0 98%
    AVE-8134 is a potent PPARα agonist, with EC50 values of 100 and 3000 nM for human and rodent PPARα receptor, respectively.
    AVE-8134
  • HY-U00052
    Silandrone 5055-42-5 98%
    Silandrone is a synthetic, orally active anabolic-androgenic steroid (AAS).
    Silandrone
  • HY-U00071
    Dobupride 106707-51-1 98%
    Dobupride is a novel gastroprokinetic agent.
    Dobupride
  • HY-U00424
    Chol-5-en-24-al-3β-ol 27460-33-9 98%
    Chol-5-en-24-al-3β-ol is a steroid compound (Vitamin D3 derivative) extracted from patent US 4354972 A, Compound IX.
    Chol-5-en-24-al-3β-ol
  • HY-U00453
    Soluble epoxide hydrolase inhibitor 1241826-88-9 98%
    Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.
    Soluble epoxide hydrolase inhibitor
  • HY-Y0004R
    2-Pyridinemethanol (Standard) 586-98-1 98%
    2-Pyridinemethanol is a pyridylalcohol, with hypoglycemic activity.
    2-Pyridinemethanol (Standard)
  • HY-Y0078R
    Cinnamyl Alcohol (Standard) 104-54-1 99.38%
    Cinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohole (HY-Y0078). This product is intended for research and analytical applications. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.
    Cinnamyl Alcohol (Standard)
  • HY-Y0078S
    Cinnamyl Alcohol-d5 1044940-87-5 98%
    Cinnamyl Alcohol-d5 is deuterated labeled Cinnamyl Alcohole (HY-Y0045). Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.
    Cinnamyl Alcohol-d5
  • HY-Y0241R
    2-Cyanopyrimidine (Standard) 14080-23-0 98%
    2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos.
    2-Cyanopyrimidine (Standard)
  • HY-Y0267R
    Phenoxyacetic acid (Standard) 122-59-8 98%
    Phenoxyacetic acid (Standard) is the analytical standard of Phenoxyacetic acid. This product is intended for research and analytical applications. Phenoxyacetic acid is an endogenous metabolite.
    Phenoxyacetic acid (Standard)
  • HY-Y0278R
    Chloranil (Standard) 118-75-2
    Chloranil (Standard) is the analytical standard of Chloranil. This product is intended for research and analytical applications. Chloranil, an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells.
    Chloranil (Standard)
  • HY-Y0289R
    1-Dodecanol (Standard) 112-53-8 99.26%
    1-Dodecanol (Standard) is the analytical standard of 1-Dodecanol. This product is intended for research and analytical applications. 1-Dodecanol is an endogenous metabolite.
    1-Dodecanol (Standard)
  • HY-Y0444R
    D-Tyrosine (Standard) 556-02-5 98%
    D-Tyrosine (Standard) is the analytical standard of D-Tyrosine (HY-Y0444). This product is intended for research and analytical applications. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
    D-Tyrosine (Standard)
  • HY-Y0586R
    2,4,5-Trimethoxybenzoic acid (Standard) 490-64-2 98%
    2,4,5-Trimethoxybenzoic acid (Standard) is the analytical standard of 2,4,5-Trimethoxybenzoic acid (HY-Y0586). This product is intended for research and analytical applications. 2,4,5-Trimethoxybenzoic acid (Asaronic acid) is a compound identified in purple perilla extracts. 2,4,5-Trimethoxybenzoic acid inhibits LPS (HY-D1056)-induced inflammatory responses, inhibits the activation of NF-κB and STAT signaling pathways. 2,4,5-Trimethoxybenzoic acid inhibits M1 macrophage phenotype-mediated inflammation in diabetes.
    2,4,5-Trimethoxybenzoic acid (Standard)
  • HY-Y0785S
    Glyoxal-d2 16355-99-0 98%
    Glyoxal-d2 is the deuterium labeled Glyoxal (HY-Y0785). Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones.
    Glyoxal-d2
  • HY-Y1009R
    Methoxyacetic acid (Standard) 625-45-6 98%
    Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether. When the concentration of methoxyacetic acid reaches a certain level, it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria. Methoxyacetic acid is somewhat toxic.
    Methoxyacetic acid (Standard)
  • HY-Y1125R
    6-Methyluracil (Standard) 626-48-2 98%
    6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo.
    6-Methyluracil (Standard)
  • HY-Y1173R
    Isethionic acid sodium salt (Standard) 1562-00-1 98%
    Isethionic acid sodium salt (Standard) is the analytical standard of Isethionic acid sodium salt (HY-Y1173). This product is intended for research and analytical applications. Isethionic acid sodium salt is an endogenous metabolite.
    Isethionic acid sodium salt (Standard)
Cat. No. Product Name / Synonyms Application Reactivity